Diabetes u dětí a dospívajících

Ondřej Cinek: Diabetes by children and adolescent

The article shows pediatric diabetes as a truly heterogeneous condition. Diabetes in children is most often caused by islet cell autoimmunity that leads to absolute lack of insulin; we discuss the recent advances in research of its etiology. A considerable proportion (estimates range from 1 to 3%) of diabetic children suffer from so called MODY diabetes, a monogenic autosomal dominant condition that is caused by a secretory defect in the beta cell. Revealing the mutation causing MODY may enable more effective diabetes therapy.